iS CLINICAL Active Serum 1 fl oz

iS CLINICAL Active Serum

$92.00

Special Offer: 25% Off Most Brands During Our July 4th Sale + Free $20 SkinMedica Travel-Size Dermal Repair Cream!

View Details

Highlights

Minimizes fine lines
Reduces blemishes

Availability depends on selected option

Buy Now, Pay Later or

Free, fast shipping all U.S. orders, no minimums. 2-3 day delivery, most orders

Learn More

Authorized Retailer

Never receive a fake product

Learn More

Product Overview

iS CLINICAL Active Serum provides a multifaceted approach to your skin concerns.

Combat the signs of aging while brightening your complexion and controlling acne with iS CLINICAL Active Serum. See a difference in your skin’s texture and tone with regular use of this astonishing facial serum. This product penetrates into the deep layers of your skin for unrivaled results at a cellular level.

An effective and lightweight treatment, iS CLINICAL Active Serum treats multiple skin problems. This anti-aging serum contains acids and botanical extracts to help correct aggravated skin while it calms irritation. With daily use, you’ll notice this advanced skin care product brighten your complexion, smooth skin texture, fight breakouts, lighten dark spots and reduce the appearance of fine lines and wrinkles.

Highlights

Minimizes fine lines
Reduces blemishes
Lightens dark spots

Ingredients

Directions

Shipping & Returns

Free U.S. Shipping. Period. View Our Shipping Policy

Return Policy: View Our Return Policy

Availability: Depends on selected option.

Questions & Answers

Submit your question about this product to our talented team of Customer Care Representatives, and we'll get back to you as soon as possible!

Ask a New Question

Product Specifications

Special Offers

25% Off Most Brands During Our July 4th Sale + Free $20 SkinMedica Travel-Size Dermal Repair Cream! Learn More

About the Brand

Featured In

Customer Reviews (357)

Overall Rating

4.7

Based on 357 reviews

Review Summary

5 Stars

306

4 Stars

3 Stars

2 Stars

1 Star

Write a Review

You can receive 50 rewards points by sharing your honest opinion of iS CLINICAL Active Serum.

Write a Review

Sort By

Read all reviews

357 Reviews

Lovelyskinat60

Verified Purchase

May 30, 2025

Love this!

I have purchased this product two times now and there is a good reason for this. I can literally feel the ingredients permeate my skin in the most pleasant and invigorating way. When first applied, there is a cool tingling sensation that lets you know that the product is doing its job. While the tingling dissipates fairly quickly, the skin brightening effects last throughout the day. I love this product and would definitely recommend .

0 people found this helpful

Mops

Verified Purchase

May 12, 2025

Is clinical active serum

I really like this serum. I’ve been using this morning and evening and I’m beginning to see results. My dark spots are lightning up, my bumpy skin spots are diminishing and my face appears slightly brighter. I’m so impressed by this serum, that I’m ordering another bottle right now.

0 people found this helpful

llhowery

Verified Purchase

April 23, 2025

Go to product

This has helped my pore size and combats the occasional acne I get. Would purchase again and again

1 person found this helpful

LovelySkin Customer

Verified Purchase

February 23, 2025

Not for my sensitive skin

I wanted to love this product, but it literally burned my skin!

0 people found this helpful

TWood

Verified Purchase

December 30, 2024

It’s great.

I use this with the pro heal serum. I think this combination is amazing. I see a big difference in my skin after a few weeks. This is worth it and way easier on the pocketbook than other brands.

0 people found this helpful

MAJ

Verified Purchase

December 26, 2024

Why is this so good?

Skincare product junky here. I’ve had this serum on my list to try for years. Finally tried it at the age of 51. It’s rare I put something on my face and feel like I see a difference on day one but the serum did that for me. Everyone is different, but my mature skin loves this.

1 person found this helpful

Supernova3

Verified Purchase

December 26, 2024

Healthy skin

iS Clinical Active Serum is a powerful, multitasking product that smooths, brightens, and clears skin. It absorbs quickly, feels refreshing, and delivers visible results in weeks. A must-try for radiant, healthy skin!

0 people found this helpful

Vuitton24

Verified Purchase

December 16, 2024

Hype is real

I had been using a competing AHA clearing serum with little results, until changing to this tingly sensational serum that keeps breakouts at bay, controls oil, and infuses skin depth botanicals. Lovely product with great effectiveness that I incorporate every other night.

0 people found this helpful

MissG

Verified Purchase

November 21, 2024

MissG

I love this product! It always helps with my breakouts. I love the tingly sensation! Let’s me know it’s working!

0 people found this helpful

LovelySkin Customer

Verified Purchase

November 13, 2024

Relief for my face

I tried this serum first as a sample I received. It helped to heal itchy burning red spots I got after blue light therapy. I have now purchased my 2nd bottle. Very few drops mixed with hydrologic serum and put it all over my face. And if spots are being more severe I put it straight on. I use this and the pro-heal serum which is made by this company. My face texture has gotten more smooth and looks better. I will be continuing to use these products. Highly recommend this product.

0 people found this helpful

Diana445

Verified Purchase

November 13, 2024

A MUST HAVE FOR YOUR SKIN CARE ROUTINE!

I’ve been using this serum for almost 10 years and will never go without it! It’s the one consistent product in my skincare routine that keeps my pores small and breakouts minimal. While the cost might seem like a lot, the bottle lasts at least 6 months if you use the product correctly! I typically use it in my nighttime routine and will put about 4-5 drops in my palm then use my finger to tap it around my face and neck. If you’re going to implement any product into your routine I highly suggest this one!

0 people found this helpful

LovelySkin Customer

Verified Purchase

November 03, 2024

Instant results

I first tried this as a sample and noticed results instantly which is why I've now ordered this product multiple times. My texture and tightness were improved not only with regular use but when applying under makeup in the morning. It gives a beautiful glow and healthy dewy look. It's really the biggest game changer I've stumbled across

0 people found this helpful

LovelySkin Customer

Verified Purchase

October 03, 2024

Work Well

I have sensitive skin and this serum does not irritate at all.

0 people found this helpful

LovelySkin Customer

Verified Purchase

August 17, 2024

Has improved the texture of my face

This serum has brightened and improved the texture of my skin. It does have a sting when you apply it.

0 people found this helpful

LovelySkin Customer

Verified Purchase

July 24, 2024

Active Serum

I love the Active Serum and use it in conjunction with the Active Peel. It keeps my skin smooth and exfoliated. Either of those would be beneficial but both together are absolutely amazing for skin resurfacing and clarity.

0 people found this helpful

Verified Purchase

July 22, 2024

clears up pores

I gave this to my 13 year old daughter. This product worked wonder clearing up pores on her T-zone area. It's pricey but will continue to buy it for her.

0 people found this helpful

LovelySkin Customer

Verified Purchase

July 12, 2024

Spicy but effective

I tend to have a bit more oily skin in the summer and more acne breakouts. This serum helps keep my skin clear. It is a bit spicy at first use.

0 people found this helpful

LovelySkin Customer

Verified Purchase

June 29, 2024

SO good for blemishes

Love this for whenever I am getting a blemish. Within a day or two the blemish disappears. I just spot treat it when needed. If you use it everyday and all over your face it can dry your skin out but for spot treatment it is the best I have used. Will not be without it!

0 people found this helpful

selkie

June 03, 2024

Really happy with IS Clinical

I was surprised at how effective this product is. I follow it with another hydrating product. I also alternate it nightly with prescription Tretinoin cream that I use alone. I received this as a free full-size gift.

1 person found this helpful

AlohaElise

Verified Purchase

May 26, 2024

CLEARS SKIN+SO GENTLE!

CLEARS SKIN+SO GENTLE LIKE WATER!

0 people found this helpful

Read All 357 Reviews +

Load More Reviews +

Your cart is empty

iS CLINICAL Active Serum

Product Overview

iS CLINICAL Active Serum provides a multifaceted approach to your skin concerns.

Highlights

Ingredients

Directions

Shipping & Returns

Questions & Answers

Product Specifications

Special Offers

About the Brand

Featured In

Customer Reviews (357)

Overall Rating

Review Summary

Write a Review

Love this!

Is clinical active serum

Go to product

Not for my sensitive skin

It’s great.

Why is this so good?

Healthy skin

Hype is real

MissG

Relief for my face

A MUST HAVE FOR YOUR SKIN CARE ROUTINE!

Instant results

Work Well

Has improved the texture of my face

Active Serum

clears up pores

Spicy but effective

SO good for blemishes

Really happy with IS Clinical

CLEARS SKIN+SO GENTLE!

Top Picks